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Macvestin-500 contains Univestin 500 mg
Univestin® is a specially formulated, patented natural food-based composition clinically proven to alleviate joint discomfort, reduce stiffness and improve mobility.
What makes Univestin® Unique?
- Univestin® is a combination of extracts prepared from two medicinal plants that have a long legacy of safe human consumption.
- Univestin® was shown to be safe and efficacious in extensive preclinical animal testing.
Key Benefits*
- Clinically proven to provide rapid and long lasting relief from joint discomfort.
- Improves range of motion, flexibility and physical function.
- Natural substances with history of safe human use.
- Extensive in vivo and in vitro safety testing with no adverse effects.
- High compatibility in formulating with other ingredients.
- Patent protected.
Plant Origin
Derived from Scutellaria baicalensis and Acacia catechu
Applications
- Alleviate joint discomfort and stiffness.
- Improve mobility and range of motion.
- Enhance flexibility and physical function.
Results in 3 days*
With Univestin, consumers feel results fast.* The product’s multi-pronged mechanism of action (MOA) modulates multiple reactions at once, helping prevent escalation.* As a result, oxidative stress and processes that cause joint discomfort are neutralized more rapidly.*
How fast? A human clinical trial comparing Univestin to an active control demonstrated that Univestin delivers results in as few as 3 days.*
Joint Discomfort
Univestin reduces joint discomfort within 5 days*
Joint Stiffness and Mobility
Univestin reduces joint stiffness and increases joint mobility within 3 days*
Joint Function
Univestin improves joint function within 7 days*
Joint Range of Motion (ROM)
Univestin improves ROM within 7 days*
Proven effective for 90 days*
Consumers choose a joint health supplement they can continue to take on a recurring basis, one whose long-term effectiveness is backed by clinical results. Univestin’s continued efficacy has been clinically proven in a randomized, double-blind placebo-controlled 90-day trial.* Univestin was compared to both a placebo and an active control, WOMAC scores for joint discomfort, stiffness and physical function all showed increasing improvement from 30 to 90 days.*
Joint Discomfort
Univestin continues to reduce joint discomfort in 90-day clinical trial*
Joint Stiffness and Mobility
Univestin continues to reduce joint stiffness & increase mobility in 90-day clinical trial*
Joint Function
Univestin continues to improve joint function in 90-day clinical trial*
Safe with no side effects*
Many over-the-counter and prescription joint-health drugs can have significant side effects, (including GI, liver, kidney and cardiovascular toxicities) which limit their long-term safe use for most individuals. Concerned consumers are seeking natural joint-health solutions that have been proven safe for long-term use.
Univestin satisfies their concerns.
- Extensive safety testing animals and healthy humans
- Large, double-blind, placebo-controlled trials
- High safety scores for all tested biomarkers
A technologically smart start
Phytologix Technology
Univestin’s unique formulation was developed through Unigen’s proprietary Phytologix technology platform. This proprietary informatics database contains comprehensive botanical profiles on over 12,000 plants and data on more than 300,000 HTP fractions. Unigen scientists used these profiles to identify two plants whose actives delivered the most effective joint-health support in in vitro cell assays, Scutellaria baicalensis and Acacia catechu.*
Two trusted botanicals
Scutellaria baicalensis
Scutellaria baicalensis is one of the top 20 herbs used in Traditional Chinese Medicine (TCM). The root contains the Free-B-ring flavonoid baicalin, the compound that demonstrated the most potent free-radical scavenging and ability to maintain healthy joints.*
Acacia catechu
Acacia catechu is a plant with a long history of use in both traditional and Ayurvedic medicine. The bark contains catechin, a powerful antioxidant that demonstrated inflammation management properties.*
Univestin’s multi-channel MOA
Addresses COX-2, 5-LOX, prostaglandins, oxidative stress and ROS production*
Joint discomfort and stiffness is caused by a complex cascading reaction to thinning joint cartilage. Many joint health ingredients attempt to tamp down the body’s natural “reaction cascade” by addressing a single mechanism-of-action (MOA), but research has shown that the body often adjusts to such single-channel solutions by activating activity in other channels.
Univestin’s patented multi-channel approach combines flavonoid-enriched plant extracts that have been clinically shown to balance activity across multiple “prongs” of the reaction cascade, soothing joint discomfort and relieving stiffness.*
Univestin’s multi-pronged MOA:
- Modulates parallel enzymatic pathways (COX and LOX) that results in increased joint health support*
- Increases antioxidant activity that neutralizes ROS production and oxidative stress*
- Helps regulate gene expression that enhances the body’s response to thinning cartilage*
Backed by sound science
Research on Univestin spans over a decade and includes:
- Over a dozen research studies
- In vitro cell lab research
- In vivo animal research
- Human clinical trials
This substantial body of peer-reviewed, published and independent research demonstrates Univestin’s significant ability to relieve joint discomfort and support healthy joint function.*
Why choose Univestin?
It’s the fast-acting, long-lasting and long-term joint solution.*
By providing rapid relief for joint discomfort and stiffness, Univestin is an innovative plant-based ingredient that meets key consumer needs.* This patent-protected ingredient:
- Is clinically shown to reduce joint stiffness within 3 days*
- Is clinically shown to reduce joint discomfort within 5 days*
- Is clinically shown to increase range of motion and physical function within 7 days*
- Supports joint health through a multi-pronged mechanism of action*
- Backed by two randomized, double-blind human clinical trials
- Is proven safe through dozens of safety studies and long-term human consumption
- Provides potent antioxidant activity*
- Promotes healthy aging and overall wellbeing*
- Undergoes stringent QA processes for guaranteed purity and potency
Additional advantages for formulators
- Combines concentrated, standardized extracts from two botanicals with long-standing use
- Is backed by solid scientific research
- Uses an all-natural aqueous extraction process
- Small dosage size (250mg/day) = small pill
- Can be used as a free-standing product or blended with other ingredients
- Has completed dozens of safety tests for a wide range of bodily systems
- Maintains rigorous quality assurance protocols and complies with all GMO regulations
- Guards against adulteration by stringent raw materials testing and identification procedures
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